Research on early diagnosis and impact prognostic factors of herpes simplex encephalitis

Objective: This study aimed to analyze the clinical characteristics, pristine diagnosis and the effect of therapy of Herpes simplex virus encephalitis (HSE) in children and discuss the factors influencing the prognosis and in pristine diagnosis. Method: Thirty-six patients were enrolled into this study if they were diagnosed as having encephalitis and also had positive polymerase chain reaction (PCR) for herpes simplex virus (HSV) from cerebrospinal fluid, and/or positive immunoglobulin M. It were observed and were followed-up that the clinical characteristics, the method of PCR and the effect of acyalovir from 1 year to 5 years. Results: Thirty-six patients were enrolled in this study. Twenty four patients 24 (67%) had good outcome and 12 (33%) had poor outcome. Fever 28 (78%) was the most common finding at admission, followed by seizures 17 (47%), lethargy 15 (42%), Coma in 12 cases (33%), vomiting in 12 cases (33%), behavioral change in 5 patients (14%), headache in 3 patients (8%), CT/MRI in 14 patients (39%), and EEG in 19 patients (52%). Conclusion: In children with central nervous system infection, routine examination of cerebrospinal fluid and detection of herpes simplex virus -1-IgM were done, Early to do brain magnetic resonance and EEG examination, early detection, early diagnosis, early treatment, prevent the occurrence of poor prognosis group, avoid sequelae.